ACKR1

Chr 1q23.2

atypical chemokine receptor 1 (Duffy blood group)

Aliases:: CCBP1, GPD, Dfy, CD234
MANE:: ENST00000368122.4

OMIM: 613665 ↗NCBI: 2532 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

ACKR1 · Q16570

v62025-08-01

Predicted Aligned Error matrix for ACKR1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.3/ 100

Confident

336 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)28%
Low(50–70)7%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

neutropenia
0.43
Decreased total leukocyte count
0.43
idiopathic aplastic anemia
0.39
functional neutrophil defect
0.39
aging
0.31
Pancytopenia
0.31
response to clozapine
0.31
microscopic polyangiitis
0.25
mathematical ability
0.14
neoplasm
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Atypical chemokine receptor 1

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels