ACP4

Chr 19q13.33

acid phosphatase 4

MANE:: ENST00000270593.2

OMIM: 606362 ↗NCBI: 93650 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ACP4 · Q9BZG2

v62025-08-01

Predicted Aligned Error matrix for ACP4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.6/ 100

Confident

426 residues

Confidence breakdown

Very high(≥ 90)74%
Confident(70–90)10%
Low(50–70)8%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Hypoplastic amelogenesis imperfecta
0.78
amelogenesis imperfecta, type 1J
0.69
amelogenesis imperfecta
0.18
amelogenesis imperfecta type 1
0.12
Hypomaturation amelogenesis imperfecta
0.10
nephrolithiasis
0.10
amelogenesis imperfecta, IIa 1K
0.07
amelogenesis imperfecta hypomaturation type 2A4
0.07
amelogenesis imperfecta type 3B
0.07
amelogenesis imperfecta, type 3A
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Testicular acid phosphatase

Protein tyrosine phosphatase that dephosphorylates the receptor tyrosine-protein kinase ERBB4, thereby inhibiting its ligand-induced proteolytic cleavage (PubMed:15219672). Involved in odontogenesis (PubMed:27843125). Regulates odontoblast cell fate via its extracellular catalytic domain by inhibiting proliferation and promoting differentiation (By similarity)