AlphaFold predicted structure
ACP5 · P13686
Mean pLDDT
94.6/ 100
Very high
325 residues
Confidence breakdown
- Very high(≥ 90)92%
- Confident(70–90)2%
- Low(50–70)0%
- Very low(< 50)6%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ACP5
Chr 19p13.2acid phosphatase 5, tartrate resistant
- Aliases:
- TRAP, HPAP, TRAcP
- MANE:
- ENST00000648477.1
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIntracerebral calcification disorders
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalWhite matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
Spondyloenchondrodysplasia with immune dysregulation
0.82hereditary disease
0.47type 1 interferonopathy
0.46Alzheimer disease
0.33Parkinson disease
0.28lysosomal storage disease
0.28neurodegenerative disease
0.28multiple sclerosis
0.28thrombophilia
0.20Abnormality of the skeletal system
0.13
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tartrate-resistant acid phosphatase type 5
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias