ADAM metallopeptidase with thrombospondin type 1 motif 10
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Diagnostic Grade (Green)
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomalBilateral congenital or childhood onset cataracts
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalGlaucoma (developmental)
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalWeill-Marchesani syndrome
Abnormality of the skeletal system
carpal tunnel syndrome
atrial fibrillation
peripheral nervous system disorder
mononeuropathy
hereditary disease
smoking behavior
Peters anomaly
isolated aniridia
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
A disintegrin and metalloproteinase with thrombospondin motifs 10
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues
ADAMTS10 · Q9H324
Mean pLDDT
73.8/ 100
Confident
1,103 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
