ADAMTS15

Chr 11q24.3

ADAM metallopeptidase with thrombospondin type 1 motif 15

MANE:: ENST00000299164.4

OMIM: 607509 ↗NCBI: 170689 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ADAMTS15 · Q8TE58

v62025-08-01

Predicted Aligned Error matrix for ADAMTS15 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.5/ 100

Confident

950 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)46%
Low(50–70)10%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

arthrogryposis, distal, type 12
0.67
neurodegenerative disease
0.32
distal arthrogryposis
0.19
idiopathic pulmonary fibrosis
0.13
liver disorder
0.12
biliary tract disorder
0.11
tooth disorder
0.11
exostosis
0.11
cellulitis
0.11
abscess
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

A disintegrin and metalloproteinase with thrombospondin motifs 15

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration