ADAMTS2

Chr 5q35.3

ADAM metallopeptidase with thrombospondin type 1 motif 2

Aliases:: ADAMTS-3, hPCPNI, PCINP, ADAM-TS2, NPI
MANE:: ENST00000251582.12

OMIM: 604539 ↗NCBI: 9509 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

ADAMTS2 · O95450

v62025-08-01

Predicted Aligned Error matrix for ADAMTS2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.1/ 100

Confident

1,211 residues

Confidence breakdown

Very high(≥ 90)15%
Confident(70–90)51%
Low(50–70)12%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ehlers Danlos syndrome with a likely monogenic cause
BIALLELIC, autosomal or pseudoautosomal
Pneumothorax - familial
Rare genetic inflammatory skin disorders
BIALLELIC, autosomal or pseudoautosomal
Thoracic aortic aneurysm or dissection
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Thoracic aortic aneurysm or dissection (GMS)
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Ehlers-Danlos syndrome, dermatosparaxis type
0.75
ankylosing spondylitis
0.32
Abnormal nasolacrimal system morphology
0.31
placental abruption
0.29
benign neoplasm
0.28
drug allergy
0.27
chondrocalcinosis
0.27
methicillin-resistant staphylococcus aureus infectious disease
0.27
Proptosis
0.27
Abnormality of the skeletal system
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

A disintegrin and metalloproteinase with thrombospondin motifs 2

Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed:31152061)