ADAMTS9

Chr 3p14.1

ADAM metallopeptidase with thrombospondin type 1 motif 9

Aliases:: KIAA1312
MANE:: ENST00000498707.5

OMIM: 605421 ↗NCBI: 56999 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ADAMTS9 · Q9P2N4

v62025-08-01

Predicted Aligned Error matrix for ADAMTS9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.1/ 100

Low

1,935 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)47%
Low(50–70)28%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Renal ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Tubulointerstitial kidney disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

type 2 diabetes mellitus
0.52
diabetes mellitus
0.48
nephronophthisis
0.45
smoking behavior
0.44
Abnormality of the skeletal system
0.44
age-related macular degeneration
0.42
colorectal cancer
0.41
gout
0.41
prostate carcinoma
0.38
COVID-19
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

A disintegrin and metalloproteinase with thrombospondin motifs 9

Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos