AlphaFold predicted structure
ADAT3 · Q96EY9
Mean pLDDT
88.3/ 100
Confident
351 residues
Confidence breakdown
- Very high(≥ 90)77%
- Confident(70–90)11%
- Low(50–70)4%
- Very low(< 50)8%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ADAT3
Chr 19p13.3adenosine deaminase tRNA specific 3
- Aliases:
- TAD3
- MANE:
- ENST00000329478.4
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalEarly onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
intellectual disability-strabismus syndrome
0.72neurodegenerative disease
0.48hereditary disease
0.19microcephaly
0.11neurodevelopmental disorder
0.03cancer
0.03Intellectual disability
0.02cervical carcinoma
0.01Neurodevelopmental delay
0.01Strabismus
0.01
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3
Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Required for binding of the ADAT2-ADAT3 complex to tRNA through its N-terminus, which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function