AGMO

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

• Severe microcephaly

  BIALLELIC, autosomal or pseudoautosomal

• Early onset or syndromic epilepsy

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• type 2 diabetes mellitus

  0.36

• hypercholesterolemia, familial, 1

  0.33

• placental retention

  0.32

• major depressive disorder

  0.32

• aortic disorder

  0.31

• vertebral disorder

  0.30

• spinal stenosis

  0.30

• vascular disorder

  0.29

• vein disorder

  0.29

• lymphatic system disorder

  0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)