AGO1

Chr 1p34.3

argonaute RISC component 1

Aliases:: hAGO1
MANE:: ENST00000373204.6

OMIM: 606228 ↗NCBI: 26523 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

AGO1 · Q9UL18

v62025-08-01

Predicted Aligned Error matrix for AGO1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.0/ 100

Very high

857 residues

Confidence breakdown

Very high(≥ 90)79%
Confident(70–90)16%
Low(50–70)1%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures
0.80
cancer
0.47
complex neurodevelopmental disorder
0.46
neurodegenerative disease
0.44
hereditary disease
0.41
Intellectual disability
0.40
Seizure
0.34
Severe intellectual disability
0.34
Tremor
0.34
Self-injurious behavior
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein argonaute-1

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)