AGPAT3

Chr 21q22.3

1-acylglycerol-3-phosphate O-acyltransferase 3

Aliases:: LPAAT-gamma, LPAAT3, LPLAT3
MANE:: ENST00000291572.13

OMIM: 614794 ↗NCBI: 56894 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

AGPAT3 · Q9NRZ7

v62025-08-01

Predicted Aligned Error matrix for AGPAT3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.6/ 100

Very high

376 residues

Confidence breakdown

Very high(≥ 90)94%
Confident(70–90)3%
Low(50–70)2%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Intellectual disability
0.38
prostate carcinoma
0.28
drug allergy
0.21
neurodevelopmental disorder
0.18
inherited retinal dystrophy
0.17
adverse effect
0.15
idiopathic generalized epilepsy
0.15
tooth disorder
0.15
retinitis pigmentosa
0.09
Cone rod dystrophy
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity)