AGT

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• CAKUT

  BIALLELIC, autosomal or pseudoautosomal

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Paediatric disorders - additional genes

  BIALLELIC, autosomal or pseudoautosomal

• Unexplained kidney failure in young people

  BIALLELIC, autosomal or pseudoautosomal

• Unexplained young onset end-stage renal disease - additional genes

  BIALLELIC, autosomal or pseudoautosomal

• Ductal plate malformation

  BIALLELIC, autosomal or pseudoautosomal

• Extreme early-onset hypertension

  Unknown

• Intellectual disability

Disease associations (Open Targets)

• renal tubular dysgenesis

  0.73

• renal tubular dysgenesis of genetic origin

  0.69

• essential hypertension

  0.63

• hypertensive disorder

  0.61

• cardiovascular disorder

  0.49

• essential hypertension, genetic

  0.48

• atrial fibrillation

  0.45

• Increased blood pressure

  0.45

• coronary artery disorder

  0.39

• congenital anomaly of kidney and urinary tract

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with AGT

Curated MONDO disease pages that list AGT among their top associated genes.

• essential hypertensionRare