AICDA

Chr 12p13.31

activation induced cytidine deaminase

Aliases:: HIGM2, CDA2, ARP2, AID
MANE:: ENST00000229335.11

OMIM: 605257 ↗NCBI: 57379 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

AICDA · Q9GZX7

v62025-08-01

Predicted Aligned Error matrix for AICDA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.2/ 100

Confident

198 residues

Confidence breakdown

Very high(≥ 90)72%
Confident(70–90)14%
Low(50–70)13%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Infantile enterocolitis & monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Gastrointestinal epithelial barrier disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hyper-IgM syndrome type 2
0.83
hereditary disease
0.19
B-cell chronic lymphocytic leukemia
0.12
diffuse large B-cell lymphoma
0.11
acute lymphoblastic leukemia
0.11
cancer
0.11
infection
0.10
myeloid sarcoma
0.10
lymphoma
0.09
Alzheimer disease
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Single-stranded DNA cytosine deaminase

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894)