AIMP2

Chr 7p22.1

aminoacyl tRNA synthetase complex interacting multifunctional protein 2

Aliases:: p38, PRO0992, JTV-1, JTV1
MANE:: ENST00000223029.8

OMIM: 600859 ↗NCBI: 7965 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

AIMP2 · Q13155

v62025-08-01

Predicted Aligned Error matrix for AIMP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.1/ 100

Confident

320 residues

Confidence breakdown

Very high(≥ 90)58%
Confident(70–90)15%
Low(50–70)13%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

leukodystrophy, hypomyelinating, 17
0.61
hereditary disease
0.49
Neurodevelopmental abnormality
0.11
Parkinson disease
0.11
cancer
0.10
lung carcinoma
0.10
lung cancer
0.10
neoplasm
0.09
nasopharyngeal carcinoma
0.08
acute myeloid leukemia
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor