AlphaFold predicted structure
AIP · O00170
Mean pLDDT
90.9/ 100
Very high
330 residues
Confidence breakdown
- Very high(≥ 90)77%
- Confident(70–90)16%
- Low(50–70)3%
- Very low(< 50)3%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
AIP
Chr 11q13.2AHR interacting HSP90 co-chaperone
- Aliases:
- XAP2, ARA9, FKBP16, FKBP37
- MANE:
- ENST00000279146.8
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEndocrine neoplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMultiple endocrine tumours
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedAdult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownParathyroid Cancer
Disease associations (Open Targets)
growth hormone-secreting pituitary adenoma
0.77familial isolated pituitary adenoma
0.73growth hormone secreting pituitary adenoma 1
0.67Inherited cancer-predisposing syndrome
0.55hereditary neoplastic syndrome
0.55pituitary tumor
0.47prolactin-producing pituitary gland adenoma
0.47ACTH-producing pituitary gland adenoma
0.46Cushing syndrome
0.46malignant endocrine neoplasm
0.46
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Small ribosomal subunit protein bS22, mitochondrial
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation