ALPI

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• inflammatory bowel disease

  0.50

• neurodegenerative disease

  0.36

• vertebral column disorder

  0.28

• urolithiasis

  0.27

• response to antibiotic

  0.23

• autoimmune disorder of central nervous system

  0.22

• chronic primary adrenal insufficiency

  0.14

• familial glucocorticoid deficiency

  0.14

• Progressive visual loss

  0.10

• type 2 diabetes mellitus

  0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with ALPI

Curated MONDO disease pages that list ALPI among their top associated genes.

• inflammatory bowel diseaseRare