AlphaFold predicted structure
AMBN · Q9NP70
Mean pLDDT
43.7/ 100
Very low
447 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)3%
- Low(50–70)14%
- Very low(< 50)83%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
AMBN
Chr 4q13.3ameloblastin
- MANE:
- ENST00000322937.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Amelogenesis imperfecta
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
amelogenesis imperfecta
0.59Hypoplastic amelogenesis imperfecta
0.59plasma cell myeloma
0.10Hypomaturation amelogenesis imperfecta
0.09tooth agenesis
0.07osteosarcoma
0.06amelogenesis imperfecta hypomaturation type 2A4
0.06amelogenesis imperfecta, type 3A
0.06amelogenesis imperfecta, type 1J
0.06dentinogenesis imperfecta type 3
0.06
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ameloblastin
Involved in the mineralization and structural organization of enamel