ANGPTL6

Chr 19p13.2

angiopoietin like 6

Aliases:: ARP5, AGF
MANE:: ENST00000253109.5

OMIM: 609336 ↗NCBI: 83854 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ANGPTL6 · Q8NI99

v62025-08-01

Predicted Aligned Error matrix for ANGPTL6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.8/ 100

Confident

470 residues

Confidence breakdown

Very high(≥ 90)42%
Confident(70–90)24%
Low(50–70)10%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cerebral vascular malformations
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Familial cerebral saccular aneurysm
0.37
brain aneurysm
0.37
neurodegenerative disease
0.27
narcolepsy-cataplexy syndrome
0.16
hypertensive disorder
0.14
pericarditis
0.11
hepatocellular carcinoma
0.10
metabolic syndrome
0.10
obesity due to melanocortin 4 receptor deficiency
0.09
Hashimoto thyroiditis
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Angiopoietin-related protein 6

May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure