ANKRD26

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bleeding and platelet disorders

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Cytopenia - NOT Fanconi anaemia

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Haematological malignancies cancer susceptibility

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Haematological malignancies for rare disease

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Inherited bleeding disorders

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Inherited predisposition to acute myeloid leukaemia (AML)

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

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Disease associations (Open Targets)

• thrombocytopenia 2

  0.78

• Thrombocytopenia

  0.76

• hereditary thrombocytopenia with normal platelets

  0.66

• acute myeloid leukemia

  0.38

• autosomal thrombocytopenia with normal platelets

  0.37

• inherited bleeding disorder, platelet-type

  0.34

• hereditary neoplastic syndrome

  0.30

• Inherited cancer-predisposing syndrome

  0.30

• dyshidrosis

  0.24

• tuberculosis

  0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)