AlphaFold predicted structure
ANLN · Q9NQW6
Mean pLDDT
59.2/ 100
Low
1,124 residues
Confidence breakdown
- Very high(≥ 90)24%
- Confident(70–90)13%
- Low(50–70)8%
- Very low(< 50)55%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ANLN
Chr 7p14.2anillin, actin binding protein
- Aliases:
- ANILLIN, Scraps, scra
- MANE:
- ENST00000265748.7
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Proteinuric renal disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
familial idiopathic steroid-resistant nephrotic syndrome
0.66focal segmental glomerulosclerosis
0.58alcohol drinking
0.31seasonal allergic rhinitis
0.31prostate carcinoma
0.30Hirsutism
0.29neurodegenerative disease
0.21splenic disorder
0.21coronary artery disorder
0.16hepatocellular carcinoma
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Anillin
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636)
Diseases associated with ANLN
Curated MONDO disease pages that list ANLN among their top associated genes.