APC regulator of Wnt signaling pathway
Annotations refreshed 1 month ago.
Diagnostic Grade (Green)
Additional findings health related
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdditional findings health related - children
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdditional findings health related - CNV analysis children
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAPC associated Polyposis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownBrain cancer pertinent cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedChildhood solid tumours
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown+8 more panels — install the extension to see the full list inline on any page.
familial adenomatous polyposis 1
Familial adenomatous polyposis
gastric adenocarcinoma and proximal polyposis of the stomach
classic familial adenomatous polyposis
colon carcinoma
colorectal adenocarcinoma
colorectal cancer
colonic neoplasm
hepatocellular carcinoma
desmoid tumor
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Adenomatous polyposis coli protein
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization
Curated MONDO disease pages that list APC among their top associated genes.
APC · P25054
Mean pLDDT
Not published
AlphaFold has not published a prediction for this sequence. This is common for very long proteins.
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
