AlphaFold predicted structure
APOC2 · P02655
Mean pLDDT
65.9/ 100
Low
101 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)43%
- Low(50–70)48%
- Very low(< 50)10%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
APOC2
Chr 19q13.32apolipoprotein C2
- MANE:
- ENST00000252490.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Familial chylomicronaemia syndrome (FCS)
BIALLELIC, autosomal or pseudoautosomalHereditary systemic amyloidosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalPeriodic fever syndromes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedSevere hypertriglyceridaemia
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalChildhood onset dystonia, chorea or related movement disorder
Familial hypercholesterolaemia
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
familial apolipoprotein C-II deficiency
0.77Hyperlipoproteinemia type 1
0.66Abnormality of the cardiovascular system
0.47familial chylomicronemia syndrome
0.38amyloidosis
0.38Alzheimer disease
0.26coronary artery disorder
0.18Hypercholesterolemia
0.16heart disorder
0.15hyperlipidemia
0.14
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Apolipoprotein C-II
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL