ARAP3

Chr 5q31.3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Aliases:: FLJ21065, DRAG1
MANE:: ENST00000239440.9

OMIM: 606647 ↗NCBI: 64411 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ARAP3 · Q8WWN8

v62025-08-01

Predicted Aligned Error matrix for ARAP3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.3/ 100

Low

1,544 residues

Confidence breakdown

Very high(≥ 90)21%
Confident(70–90)40%
Low(50–70)6%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary lymphoedema
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Rare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

upper respiratory tract disorder
0.33
mathematical ability
0.32
Varicose veins
0.26
alcohol drinking
0.26
ocular hypotension
0.22
lymphedema
0.19
insomnia
0.17
coronary atherosclerosis
0.15
Parkinson disease
0.13
prostate cancer
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin