ARHGAP19

Chr 10q24.1

Rho GTPase activating protein 19

Aliases:: FLJ00194, MGC14258
MANE:: ENST00000358531.9

OMIM: 611587 ↗NCBI: 84986 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ARHGAP19 · Q14CB8

v62025-08-01

Predicted Aligned Error matrix for ARHGAP19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.6/ 100

Low

494 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)24%
Low(50–70)7%
Very low(< 50)35%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hereditary neuropathy
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

motor peripheral neuropathy
0.46
Abnormality of the skeletal system
0.32
type 2 diabetes mellitus
0.30
risk-taking behaviour
0.24
methicillin-resistant staphylococcus aureus infectious disease
0.24
Abnormal blistering of the skin
0.24
diabetes mellitus
0.22
attention deficit-hyperactivity disorder
0.14
major depressive disorder
0.14
vulvitis
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Rho GTPase-activating protein 19

Has GTPase activator activity toward RHOA; RHOA activation results in GTP hydrolysis and conversion from an active GTP-bound to an inactive GDP-bound state (PubMed:24259668, PubMed:41086021). Lacks GTPase activator activity toward RAC1 or CDC42 (PubMed:24259668)