Rho GDP dissociation inhibitor alpha
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomalUnexplained kidney failure in young people
BIALLELIC, autosomal or pseudoautosomalnephrotic syndrome, type 8
familial idiopathic steroid-resistant nephrotic syndrome
neurodegenerative disease
nephrotic syndrome
Familial advanced sleep-phase syndrome
hereditary disease
congenital nephrotic syndrome, Finnish type
chronic kidney disease
glioma
central nervous system cancer
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Rho GDP-dissociation inhibitor 1
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1
ARHGDIA · P52565
Mean pLDDT
90.3/ 100
Very high
204 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
