AlphaFold predicted structure
ARHGEF10 · O15013
Mean pLDDT
64.9/ 100
Low
1,369 residues
Confidence breakdown
- Very high(≥ 90)35%
- Confident(70–90)20%
- Low(50–70)8%
- Very low(< 50)37%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ARHGEF10
Chr 8p23.3Rho guanine nucleotide exchange factor 10
- Aliases:
- KIAA0294, Gef10
- MANE:
- ENST00000349830.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
autosomal dominant slowed nerve conduction velocity
0.52Charcot-Marie-Tooth disease
0.31alcohol drinking
0.28stroke disorder
0.27response to polyunsaturated fatty acid supplementation
0.26dementia
0.24atrial septal defect
0.24myeloid leukemia
0.22non-small cell lung carcinoma
0.21small cell lung carcinoma
0.21
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Rho guanine nucleotide exchange factor 10
May play a role in developmental myelination of peripheral nerves