ARPC1B

Chr 7q22.1

actin related protein 2/3 complex subunit 1B

Aliases:: ARC41, p40-ARC, p41-ARC
MANE:: ENST00000646101.2

OMIM: 604223 ↗NCBI: 10095 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

ARPC1B · O15143

v62025-08-01

Predicted Aligned Error matrix for ARPC1B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.4/ 100

Very high

372 residues

Confidence breakdown

Very high(≥ 90)86%
Confident(70–90)6%
Low(50–70)6%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
0.77
combined immunodeficiency
0.43
Combined T and B cell immunodeficiency
0.43
autoimmune disorder of central nervous system
0.40
cutaneous leishmaniasis
0.37
neurodegenerative disease
0.34
immunodeficiency disease
0.34
placental retention
0.22
schizophrenia
0.21
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Actin-related protein 2/3 complex subunit 1B

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)