ARPC4

Chr 3p25.3

actin related protein 2/3 complex subunit 4

Aliases:: p20-Arc, ARC20
MANE:: ENST00000397261.8

OMIM: 604226 ↗NCBI: 10093 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

ARPC4 · P59998

v62025-08-01

Predicted Aligned Error matrix for ARPC4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.3/ 100

Very high

168 residues

Confidence breakdown

Very high(≥ 90)91%
Confident(70–90)8%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Severe microcephaly
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodegenerative disease
0.56
developmental delay, language impairment, and ocular abnormalities
0.55
microcephaly
0.37
cutaneous leishmaniasis
0.37
Alzheimer disease
0.35
Parkinson disease
0.35
multiple sclerosis
0.35
lysosomal storage disease
0.35
hereditary disease
0.19
eye swelling
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Actin-related protein 2/3 complex subunit 4

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)