ARPC5

Chr 1q25.3

actin related protein 2/3 complex subunit 5

Aliases:: p16-Arc, ARC16, dJ127C7.3
MANE:: ENST00000359856.11

OMIM: 604227 ↗NCBI: 10092 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

ARPC5 · O15511

v62025-08-01

Predicted Aligned Error matrix for ARPC5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.2/ 100

Very high

151 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)10%
Low(50–70)7%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
immunodeficiency 113 with autoimmunity and autoinflammation
0.42
combined immunodeficiency
0.37
severe combined immunodeficiency
0.37
cutaneous leishmaniasis
0.37
autoimmune disorder of central nervous system
0.32
hereditary disease
0.19
Bicuspid aortic valve
0.11
Miyoshi myopathy
0.10
hepatocellular carcinoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Actin-related protein 2/3 complex subunit 5

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)