ATF3

Chr 1q32.3

activating transcription factor 3

MANE:: ENST00000341491.9

OMIM: 603148 ↗NCBI: 467 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ATF3 · P18847

v62025-08-01

Predicted Aligned Error matrix for ATF3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.9/ 100

Confident

181 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)28%
Low(50–70)14%
Very low(< 50)21%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

cardiac transplant
0.21
blood coagulation disease
0.18
Abnormality of limbs
0.17
breast carcinoma
0.13
neoplasm
0.12
hepatocellular carcinoma
0.12
breast cancer
0.11
cancer
0.11
colorectal carcinoma
0.11
prostate carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclic AMP-dependent transcription factor ATF-3

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter