AlphaFold predicted structure
ATG5 · Q9H1Y0
Mean pLDDT
93.3/ 100
Very high
275 residues
Confidence breakdown
- Very high(≥ 90)81%
- Confident(70–90)15%
- Low(50–70)3%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ATG5
Chr 6q21autophagy related 5
- Aliases:
- ASP, APG5, hAPG5
- MANE:
- ENST00000369076.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
COVID-19 research
Unknown
Disease associations (Open Targets)
neurodegenerative disease
0.56rheumatoid arthritis
0.40asthma
0.39systemic lupus erythematosus
0.36plasma cell myeloma
0.34renal osteodystrophy
0.29childhood onset asthma
0.28cervical carcinoma
0.28systemic sclerosis
0.28lysosomal storage disease
0.28
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Autophagy protein 5
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity)