AlphaFold predicted structure
AXIN2 · Q9Y2T1
Mean pLDDT
60.5/ 100
Low
843 residues
Confidence breakdown
- Very high(≥ 90)22%
- Confident(70–90)15%
- Low(50–70)14%
- Very low(< 50)50%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
AXIN2
Chr 17q24.1axin 2
- Aliases:
- MGC126582, DKFZp781B0869
- MANE:
- ENST00000307078.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited polyposis and early onset colorectal cancer - germline testing
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedRare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
oligodontia-cancer predisposition syndrome
0.75colorectal cancer
0.63AXIN2-related attenuated familial adenomatous polyposis
0.61Inherited cancer-predisposing syndrome
0.56hereditary neoplastic syndrome
0.56Oligodontia - cancer predisposition syndrome
0.53colon carcinoma
0.46Oligodontia
0.45prostate carcinoma
0.38skin squamous cell carcinoma
0.38
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Axin-2
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B
Diseases associated with AXIN2
Curated MONDO disease pages that list AXIN2 among their top associated genes.