AlphaFold predicted structure
B2M · P61769
Mean pLDDT
94.1/ 100
Very high
119 residues
Confidence breakdown
- Very high(≥ 90)83%
- Confident(70–90)11%
- Low(50–70)6%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
B2M
Chr 15q21.1beta-2-microglobulin
- MANE:
- ENST00000648006.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalHereditary systemic amyloidosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPeriodic fever syndromes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
Immunodeficiency by defective expression of HLA class 1
0.66diffuse large B-cell lymphoma
0.59HIV infectious disease
0.53amyloidosis, hereditary systemic 6
0.53AL amyloidosis
0.47COVID-19
0.47non-Hodgkin lymphoma
0.46Familial renal amyloidosis
0.45familial visceral amyloidosis
0.45melanoma
0.42
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Beta-2-microglobulin
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)
Diseases associated with B2M
Curated MONDO disease pages that list B2M among their top associated genes.