B3GNT2

Chr 2p15

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Aliases:: B3GNT-2, BETA3GNT, B3GN-T2, B3GN-T1
MANE:: ENST00000301998.5

OMIM: 605581 ↗NCBI: 10678 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

B3GNT2 · Q9NY97

v62025-08-01

Predicted Aligned Error matrix for B3GNT2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.1/ 100

Very high

397 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)8%
Low(50–70)10%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypothyroidism
0.43
autoimmune disease
0.38
psoriasis
0.35
thyroid gland disorder
0.35
ankylosing spondylitis
0.33
rheumatoid arthritis
0.32
Hashimoto thyroiditis
0.30
Alzheimer disease
0.30
seborrheic dermatitis
0.28
erythematosquamous dermatosis
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase