AlphaFold predicted structure
BACH2 · Q9BYV9
Mean pLDDT
53.6/ 100
Low
841 residues
Confidence breakdown
- Very high(≥ 90)19%
- Confident(70–90)9%
- Low(50–70)5%
- Very low(< 50)66%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
BACH2
Chr 6q15BACH transcriptional regulator 2
- Aliases:
- BTBD25
- MANE:
- ENST00000257749.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownInfantile enterocolitis & monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPrimary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
immunodeficiency 60
0.57asthma
0.55inflammatory bowel disease
0.55hypothyroidism
0.55type 1 diabetes mellitus
0.54skin cancer
0.53skin neoplasm
0.53basal cell carcinoma
0.53thyroid gland disorder
0.52Hashimoto thyroiditis
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Transcription regulator protein BACH2
Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713)
Diseases associated with BACH2
Curated MONDO disease pages that list BACH2 among their top associated genes.