AlphaFold predicted structure
BAG3 · O95817
Mean pLDDT
57.3/ 100
Low
575 residues
Confidence breakdown
- Very high(≥ 90)18%
- Confident(70–90)6%
- Low(50–70)18%
- Very low(< 50)58%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
BAG3
Chr 10q26.11BAG cochaperone 3
- MANE:
- ENST00000369085.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Dilated and arrhythmogenic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDilated Cardiomyopathy and conduction defects
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedDistal myopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownLimb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPaediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedArthrogryposis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
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Disease associations (Open Targets)
dilated cardiomyopathy 1HH
0.82myofibrillar myopathy 6
0.79dilated cardiomyopathy
0.72familial isolated dilated cardiomyopathy
0.68cardiomyopathy
0.61heart failure
0.59hypertrophic cardiomyopathy
0.59Abnormality of the cardiovascular system
0.56familial dilated cardiomyopathy
0.51atrioventricular block
0.50
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
BAG family molecular chaperone regulator 3
Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920)
Diseases associated with BAG3
Curated MONDO disease pages that list BAG3 among their top associated genes.