BCL9L

Chr 11q23.3

BCL9 like

Aliases:: DLNB11, B9L, Bcl9-2
MANE:: ENST00000683865.1

OMIM: 609004 ↗NCBI: 283149 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

BCL9L · Q86UU0

v62025-08-01

Predicted Aligned Error matrix for BCL9L — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

42.2/ 100

Very low

1,499 residues

Confidence breakdown

Very high(≥ 90)2%
Confident(70–90)4%
Low(50–70)7%
Very low(< 50)87%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

colorectal adenocarcinoma
0.57
colon adenocarcinoma
0.40
superficial spreading melanoma
0.37
skin basal cell carcinoma
0.37
nodular malignant melanoma
0.37
gastric carcinoma
0.37
gastric intestinal type adenocarcinoma
0.37
endometrial endometrioid adenocarcinoma
0.37
cutaneous melanoma
0.37
lymphoid neoplasm
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

B-cell CLL/lymphoma 9-like protein

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)