BECN1

Chr 17q21.31

beclin 1

Aliases:: ATG6, VPS30
MANE:: ENST00000590099.6

OMIM: 604378 ↗NCBI: 8678 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

BECN1 · Q14457

v62025-08-01

Predicted Aligned Error matrix for BECN1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.6/ 100

Confident

450 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)33%
Low(50–70)12%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.55
COVID-19
0.48
dengue disease
0.37
severe acute respiratory syndrome
0.37
lysosomal storage disease
0.28
neoplasm
0.12
hepatocellular carcinoma
0.12
breast cancer
0.12
breast carcinoma
0.11
colorectal carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Beclin-1

Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense