BICD2

Chr 9q22.31

BICD cargo adaptor 2

Aliases:: KIAA0699
MANE:: ENST00000356884.11

OMIM: 609797 ↗NCBI: 23299 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

BICD2 · Q8TD16

v62025-08-01

Predicted Aligned Error matrix for BICD2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.0/ 100

Confident

824 residues

Confidence breakdown

Very high(≥ 90)50%
Confident(70–90)22%
Low(50–70)8%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Adult onset hereditary spastic paraplegia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Arthrogryposis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Hereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Paediatric motor neuronopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures
0.81
spinal muscular atrophy, lower extremity-predominant, 2B, prenatal onset, autosomal dominant
0.74
hereditary disease
0.48
neuronopathy, distal hereditary motor, autosomal dominant
0.46
arthrogryposis multiplex congenita
0.44
Decreased fetal movement
0.44
Abnormality of the skeletal system
0.40
Spastic paraplegia
0.40
hydrops fetalis
0.37
pterygium
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein bicaudal D homolog 2

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity)