BICRA

Chr 19q13.33

BRD4 interacting chromatin remodeling complex associated protein

Aliases:: SMARCK1
MANE:: ENST00000594866.3

OMIM: 605690 ↗NCBI: 29998 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

BICRA · Q9NZM4

v62025-08-01

Predicted Aligned Error matrix for BICRA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

41.9/ 100

Very low

1,560 residues

Confidence breakdown

Very high(≥ 90)4%
Confident(70–90)8%
Low(50–70)7%
Very low(< 50)82%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Coffin-Siris syndrome 12
0.71
Coffin-Siris syndrome
0.37
Intellectual disability
0.33
arthritic joint disease
0.26
atrial fibrillation
0.26
smoking initiation
0.25
placental abruption
0.20
poisoning
0.20
androgenetic alopecia
0.17
atrial flutter
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

BRD4-interacting chromatin-remodeling complex-associated protein

Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454)