AlphaFold predicted structure
BLNK · Q8WV28
Mean pLDDT
63.7/ 100
Low
456 residues
Confidence breakdown
- Very high(≥ 90)22%
- Confident(70–90)9%
- Low(50–70)35%
- Very low(< 50)33%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
BLNK
Chr 10q24.1B cell linker
- Aliases:
- SLP65, Ly57, SLP-65, BLNK-s, BASH
- MANE:
- ENST00000224337.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
isolated agammaglobulinemia
0.72autosomal agammaglobulinemia
0.47agammaglobulinemia
0.47alcohol drinking
0.29neuroendocrine neoplasm
0.26Abnormality of the gastrointestinal tract
0.22substance abuse
0.22attention deficit-hyperactivity disorder
0.22aging
0.20hereditary disease
0.19
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
B-cell linker protein
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis