AlphaFold predicted structure
BNC2 · Q6ZN30
Mean pLDDT
53.5/ 100
Low
1,099 residues
Confidence breakdown
- Very high(≥ 90)11%
- Confident(70–90)18%
- Low(50–70)7%
- Very low(< 50)64%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
BNC2
Chr 9p22.3-p22.2basonuclin zinc finger protein 2
- Aliases:
- BSN2, FLJ20043, bn2
- MANE:
- ENST00000380672.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
CAKUT
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownUnexplained young onset end-stage renal disease - additional genes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPigmentary skin disorders
Disease associations (Open Targets)
lower urinary tract obstruction, congenital
0.70fetal lower urinary tract obstruction
0.62posterior urethral valve
0.55basal cell carcinoma
0.52skin neoplasm
0.51hair color
0.51Abnormality of the skeletal system
0.51actinic keratosis
0.51skin cancer
0.50squamous cell carcinoma
0.48
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Zinc finger protein basonuclin-2
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115)
Diseases associated with BNC2
Curated MONDO disease pages that list BNC2 among their top associated genes.