BNIP1

Chr 5q35.1

BCL2 interacting protein 1

Aliases:: Nip1, SEC20
MANE:: ENST00000351486.10

OMIM: 603291 ↗NCBI: 662 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

BNIP1 · Q12981

v62025-08-01

Predicted Aligned Error matrix for BNIP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.5/ 100

Confident

228 residues

Confidence breakdown

Very high(≥ 90)28%
Confident(70–90)47%
Low(50–70)25%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

atrial fibrillation
0.29
hypertrophic pyloric stenosis
0.24
nephrolithiasis
0.14
spondyloepiphyseal dysplasia congenita
0.12
open-angle glaucoma
0.10
glaucoma
0.09
paroxysmal tachycardia
0.06
Thrombophlebitis
0.05
phlebitis
0.05
Alzheimer disease
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Vesicle transport protein SEC20

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Also plays a role in apoptosis (PubMed:15272311, PubMed:23896122, PubMed:7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable)