AlphaFold predicted structure
BRAF · P15056
Mean pLDDT
66.4/ 100
Low
766 residues
Confidence breakdown
- Very high(≥ 90)29%
- Confident(70–90)26%
- Low(50–70)6%
- Very low(< 50)39%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
BRAF
Chr 7q34B-Raf proto-oncogene, serine/threonine kinase
- Aliases:
- BRAF1, BRAF-1
- MANE:
- ENST00000646891.2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Childhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal hydrops
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIUGR and IGF abnormalities
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMonogenic short stature
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
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Disease associations (Open Targets)
cardiofaciocutaneous syndrome
0.88Noonan syndrome
0.84melanoma
0.82cardiofaciocutaneous syndrome 1
0.76Noonan syndrome 7
0.76LEOPARD syndrome 3
0.76Noonan syndrome with multiple lentigines
0.75colorectal cancer
0.75cancer
0.71lung cancer
0.70
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Serine/threonine-protein kinase B-raf
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
Diseases associated with BRAF
Curated MONDO disease pages that list BRAF among their top associated genes.