BRF2

Chr 8p11.23

BRF2 general transcription factor IIIB subunit

Aliases:: FLJ11052, BRFU, TFIIIB50
MANE:: ENST00000220659.11

OMIM: 607013 ↗NCBI: 55290 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

BRF2 · Q9HAW0

v62025-08-01

Predicted Aligned Error matrix for BRF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.3/ 100

Confident

419 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)13%
Low(50–70)8%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
Unknown
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.49
thyroiditis
0.29
multiple congenital anomalies/dysmorphic syndrome
0.23
Intellectual disability
0.19
prostate cancer
0.11
Familial prostate cancer
0.11
non-small cell lung carcinoma
0.10
cancer
0.10
breast carcinoma
0.10
breast cancer
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription factor IIIB 50 kDa subunit

General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071)