AlphaFold predicted structure
C4A · P0C0L4
Mean pLDDT
83.4/ 100
Confident
1,744 residues
Confidence breakdown
- Very high(≥ 90)44%
- Confident(70–90)43%
- Low(50–70)6%
- Very low(< 50)7%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
C4A
Chr 6p21.33complement C4A (Chido/Rodgers blood group)
- Aliases:
- CPAMD2, C4S, CO4, C4, C4A3
- MANE:
- ENST00000428956.7
Annotations refreshed 7 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
complement component 4a deficiency
0.60immunodeficiency due to a classical component pathway complement deficiency
0.56complement deficiency
0.47systemic lupus erythematosus
0.40dengue disease
0.37hereditary disease
0.19neoplasm
0.10acute myeloid leukemia
0.10Alzheimer disease
0.10age-related macular degeneration
0.10
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Complement C4-A
Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system
Diseases associated with C4A
Curated MONDO disease pages that list C4A among their top associated genes.