C5

Chr 9q33.2

complement C5

Aliases:: CPAMD4, C5a, C5b
MANE:: ENST00000223642.3

OMIM: 120900 ↗NCBI: 727 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

C5 · P01031

v62025-08-01

Predicted Aligned Error matrix for C5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.6/ 100

Confident

1,676 residues

Confidence breakdown

Very high(≥ 90)26%
Confident(70–90)60%
Low(50–70)11%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Ectodermal dysplasia
Familial cicatricial alopecia

Disease associations (Open Targets)

Immunodeficiency due to a late component of complements deficiency
0.74
paroxysmal nocturnal hemoglobinuria
0.61
myasthenia gravis
0.59
atypical hemolytic-uremic syndrome
0.54
neuromyelitis optica
0.52
age-related macular degeneration
0.49
hemolytic-uremic syndrome
0.49
Protein-losing enteropathy
0.48
atrophic macular degeneration
0.48
complement deficiency
0.47

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Complement C5

Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:6554279). Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)