CALM2

Chr 2p21

calmodulin 2

Aliases:: PHKD, PHKD2, CAMII
MANE:: ENST00000272298.12

OMIM: 114182 ↗NCBI: 805 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

CALM2 · P0DP24

v62025-08-01

Predicted Aligned Error matrix for CALM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.8/ 100

Confident

149 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)45%
Low(50–70)7%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Catecholaminergic polymorphic VT
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Long QT syndrome
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Short QT syndrome
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

long QT syndrome 15
0.79
Romano-Ward syndrome
0.63
familial long QT syndrome
0.56
long QT syndrome 1
0.54
Prolonged QT interval
0.50
bacterial infectious disease
0.50
Abnormality of the cardiovascular system
0.41
sudden infant death syndrome
0.33
alcohol drinking
0.25
catecholaminergic polymorphic ventricular tachycardia
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Calmodulin-2

Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696)