CALR

Chr 19p13.13

calreticulin

Aliases:: RO, SSA, cC1qR, CRT, FLJ26680
MANE:: ENST00000316448.10

OMIM: 109091 ↗NCBI: 811 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CALR · P27797

v62025-08-01

Predicted Aligned Error matrix for CALR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.1/ 100

Confident

417 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)20%
Low(50–70)8%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Thrombocythaemia
Other
Cytopenias and congenital anaemias
Unknown

Disease associations (Open Targets)

neoplasm
0.58
myeloproliferative disorder
0.58
thrombocythemia 1
0.57
primary myelofibrosis
0.56
hemorrhagic disease
0.54
neurodegenerative disease
0.52
essential thrombocythemia
0.45
Alzheimer disease
0.43
Parkinson disease
0.43
multiple sclerosis
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Calreticulin

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)