CARD14

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Autoinflammatory disorders

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• COVID-19 research

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Generalised pustular psoriasis

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Ichthyosis and erythrokeratoderma

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Palmoplantar keratoderma and erythrokeratodermas

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Pityriasis rubra pilaris

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Primary immunodeficiency or monogenic inflammatory bowel disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Rare genetic inflammatory skin disorders

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

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Disease associations (Open Targets)

• psoriasis 2

  0.82

• pityriasis rubra pilaris

  0.81

• familial pityriasis rubra pilaris

  0.71

• erythematosquamous dermatosis

  0.45

• psoriasis

  0.44

• skin disorder

  0.38

• seborrheic dermatitis

  0.37

• psoriasis vulgaris

  0.36

• psoriasis 14, pustular

  0.36

• cervical carcinoma

  0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)